Ulinastatin ameliorates acute kidney injury induced by crush syndrome inflammation by modulating Th17/Treg cells.
RatCrushLimb / muscle crushWistarMalen = 46 rats: normal control n = 6; model n = 10; each of three…50,000, 100,000 and 200,000 U/kg
Model: Crush syndrome-induced acute kidney injury produced with a digital crush injury device platform
Ulinastatin lowered serum blood urea nitrogen, creatine kinase, creatinine, myoglobin and potassium compared with the untreated crush syndrome group, reduced inflammatory cell infiltration and myoglobin casts, increased the proportion of CD4 positive CD25 positive Foxp3 positive regulatory T cells…
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