Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues.
MouseRadiationTransplantation up to 24 h after irradiation was still protective
Model: Lethal total body ionising irradiation (acute radiation syndrome)
Wharton's jelly mesenchymal stem cells protected mice from a lethal radiation dose even when given up to 24 h after irradiation, and adding tetracycline extended the protective window. Protection was lost when G-CSF or IL-6 were knocked down in the cells or when cells were given to Nrf-2 knockout r…
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