Novel neuroprotection using antioxidant nanoparticles in a mouse model of head trauma.
MouseTBIControlled cortical impactInstitute of Cancer Research (ICR)MaleIntravenous via the tail vein immediately after injury, then intraperitoneal for subsequent doses3 mg/kgFirst dose immediately after traumatic brain injury
Model: Head-impact model of traumatic brain injury
Nanoparticles were detected in microvessels around the injured area. Cognitive and motor behaviour was significantly better and contusion volume significantly smaller than in the other groups, superoxide scavenging capacity was higher, neuronal loss around the injury was reduced, neurodegenerative…
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