THERAPY DOSSIER · th-726b9d23dcbb

Redox-active nitroxide radical-containing nanoparticles (core-shell nanoparticles containing 4-amino-TEMPO)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32039974 ↗2020Reported benefit

Novel neuroprotection using antioxidant nanoparticles in a mouse model of head trauma.

MouseTBIControlled cortical impactInstitute of Cancer Research (ICR)MaleIntravenous via the tail vein immediately after injury, then intraperitoneal for subsequent doses3 mg/kgFirst dose immediately after traumatic brain injury

Model: Head-impact model of traumatic brain injury

Nanoparticles were detected in microvessels around the injured area. Cognitive and motor behaviour was significantly better and contusion volume significantly smaller than in the other groups, superoxide scavenging capacity was higher, neuronal loss around the injury was reduced, neurodegenerative…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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