Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation.
RatIschaemia-reperfusionCardiacSprague-DawleyMaleIntraperitoneal15 min before vascular ligation
Model: Myocardial ischaemia-reperfusion injury produced by 30 min of coronary ischaemia followed by 24 h of reperfusion; parallel in vitro anoxia/reoxygenation in H9c2 cardiomyoblasts
Scutellarin improved diastolic dysfunction, reduced myocardial structural abnormality, inhibited myocyte apoptosis and inflammation and promoted autophagy. It reduced NLRP3 inflammasome activation, inhibited mTORC1 and increased Akt phosphorylation, and the protective effect was abolished by siRNA…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.