Spatiotemporal Evolution of TCM Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai (Erigeron breviscapus)
Ischemic Strokes · Prognosis
Enrolment: 358 · Results not recorded
Loading the evidence…
Nutraceutical · No ChEMBL entry returned for scutellarin or scutellarein.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Ischemic Strokes · Prognosis
Enrolment: 358 · Results not recorded
Adverse Drug Event · Adverse Drug Reaction · Anaphylactic Reaction
Enrolment: 20000 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Myocardial ischaemia-reperfusion injury produced by 30 min of coronary ischaemia followed by 24 h of reperfusion; parallel in vitro anoxia/reoxygenation in H9c2 cardiomyoblasts
Scutellarin improved diastolic dysfunction, reduced myocardial structural abnormality, inhibited myocyte apoptosis and inflammation and promoted autophagy. It reduced NLRP3 inflammasome activation, inhibited mTORC1 and increased Akt phosphorylation, and the protective effect was abolished by siRNA…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Doxorubicin-induced acute cardiotoxicity (single intraperitoneal dose of 20 mg/kg doxorubicin); pharmacokinetic experiments used a single intravenous 5 mg/kg doxorubicin dose
Scutellarin co-treatment reduced LDH activity from 4057.8 to 2595.9, malondialdehyde from 2.083 to 1.380 nmol/mg protein and cardiac troponin T from 0.1695 to 0.0222 ng/mL, and raised LVEF from 47.75 to 76.70% and LVFS from 20.66 to 40.28%, with markedly reduced cardiac histological damage. It lowe…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.