Cardiac Nestin+ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization.
MouseIschaemia-reperfusionCardiacIntramyocardial injection
Model: Acute myocardial infarction produced by coronary ligation
Intramyocardial injection of cardiac Nestin-positive mesenchymal stromal cells significantly improved cardiac function and reduced infarct size after acute myocardial infarction compared with bone marrow-derived cells or saline. Treatment reduced pan-macrophage infiltration while inducing an M2 phe…
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