THERAPY DOSSIER · th-f9c68fb2575b

Cardiac Nestin-positive mesenchymal stromal cells (NescMSCs)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31991111 ↗2020Reported benefit

Cardiac Nestin+ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization.

MouseIschaemia-reperfusionCardiacIntramyocardial injection

Model: Acute myocardial infarction produced by coronary ligation

Intramyocardial injection of cardiac Nestin-positive mesenchymal stromal cells significantly improved cardiac function and reduced infarct size after acute myocardial infarction compared with bone marrow-derived cells or saline. Treatment reduced pan-macrophage infiltration while inducing an M2 phe…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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