The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway.
RatChemical/toxinSprague DawleyMalen = 40 male rats randomly divided into 4 groups500 IU/kg or 1000 IU/kgProphylactic, given before the acetaminophen challenge on day 7
Model: Acetaminophen overdose (2 g/kg orally on day 7) causing acute hepatic and renal injury
Vitamin D significantly improved liver and kidney function markers and histopathology, reduced hepatic malondialdehyde and increased total antioxidant capacity, and moderated the acetaminophen-induced changes in NrF2, BACH1, HO-1 and NF-kappaB. The 500 IU/kg dose gave better histopathological and i…
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