Vitamin D and Type 2 Diabetes, Treat-To-Target
Prediabetes · Type 2 Diabetes
Enrolment: 100 · Results not recorded
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Nutraceutical · Vitamin D receptor agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Prediabetes · Type 2 Diabetes
Enrolment: 100 · Results not recorded
HIV Infections · Vitamin D Deficiency
Enrolment: 45 · Results not recorded
Systemic Lupus Erythematosus
Enrolment: 7 · Results not recorded
Type 2 Diabetes
Enrolment: 48 · Results not recorded
COVID-19
Enrolment: 240 · Results not recorded
Bioavailability of Vitamin D
Enrolment: 27 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Acetaminophen overdose (2 g/kg orally on day 7) causing acute hepatic and renal injury
Vitamin D significantly improved liver and kidney function markers and histopathology, reduced hepatic malondialdehyde and increased total antioxidant capacity, and moderated the acetaminophen-induced changes in NrF2, BACH1, HO-1 and NF-kappaB. The 500 IU/kg dose gave better histopathological and i…
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Model: Single oral dose of paracetamol (acetaminophen) 1200 mg/kg causing hepatorenal injury
Both vitamin D regimens alleviated paracetamol-induced hepatorenal damage, restored 25-hydroxyvitamin D and vitamin D pathway gene expression, lowered malondialdehyde and pro-inflammatory cytokines and raised antioxidant and anti-inflammatory markers; the prophylactic protocol outperformed the ther…
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Model: Single UVB dose of 100 mJ/cm2 to a 2 cm2 depilated area of dorsal skin, producing acute sunburn-type injury
A single 5 ng intraperitoneal dose of vitamin D 1 h after UVB reduced wound area, tissue damage, inflammatory gene expression and apoptosis and expanded M2 macrophages, with protection lost when autophagy was blocked pharmacologically or by myeloid Atg7 deletion.
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Model: Chronic constriction injury of the sciatic nerve producing thermal hyperalgesia, mechanical allodynia and cold allodynia
Acute vitamin D injections at 250, 500 and 1000 unit/kg did not attenuate mechanical allodynia, cold allodynia or heat hyperalgesia compared with the injury group. Daily administration of 1000 unit/kg from the first postoperative day until day 21 considerably attenuated cold allodynia and heat hype…
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Model: Left cervical (C2) spinal cord hemisection
Vitamin D3-treated animals showed enhanced locomotor activity, improved ventilatory response to induced hindlimb muscle fatigue, H-reflex depression comparable with controls and a preserved phrenic nerve response to asphyxial stress. The reduction in axon number in the proximal stump versus sham wa…
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