Immunomodulatory role of recombinant human erythropoietin in acute kidney injury induced by crush syndrome inhibition of the TLR4/NF-kappaB signaling pathway in macrophages.

Immunomodulatory role of recombinant human erythropoietin in acute kidney injury induced by crush syndrome inhibition of the TLR4/NF-kappaB signaling pathway in macrophages.

Model: Crush syndrome-associated acute kidney injury induced by 50 per cent glycerol at 7.5 ml/kg

Recombinant human erythropoietin improved renal function and tissue damage, lowered proinflammatory cytokine production and macrophage infiltration, and downregulated TLR4 and NF-kappaB p65 expression in kidney and in myoglobin-stimulated macrophages.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.