Enhancing KCNQ Channel Activity Improves Neurobehavioral Recovery after Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-DawleyMaleAlzet osmotic pump infusion or intraperitoneal injectionTwo different concentrations were compared (values not stat…Started 3 hours or 3 days after contusion
Model: Contusive spinal cord injury at T10
Osmotic pump delivery started 3 hours after contusion improved locomotor recovery, whereas intraperitoneal delivery did not. Both delivery methods attenuated mechanical hyperreflexia and spontaneous pain, with no change in thermal threshold. Treatment started 3 days after injury reduced mechanical…
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