Neuroprotection in the Acute Stage Enables Functional Recovery Following Repair of Chronic Cervical Root Transection After a 3-Week Delay.
RatOtherSprague-DawleyFemaleAdministered during the acute stage, in the first week after transection
Model: Left sixth to eighth cervical preganglionic root transection, with nerve grafting plus acidic fibroblast growth factor and fibrin glue performed 3 weeks after injury
Sirolimus attenuated microglial and astrocytic proliferation and enhanced neuronal autophagy and survival. Only sirolimus-treated rats showed significant sensory and motor recovery after delayed repair, with abundant nerve fibres and neurons in the dorsal root entry zone, dorsal root ganglion and v…
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