Drug · FK506-binding protein 1A inhibitor (INHIBITOR)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Lymphoblastic Leukaemia · Acute Myeloid Leukaemia · Myelodysplastic Syndrome
Enrolment: 15 · Results not recorded
Kidney Failure · Kidney Diseases
Enrolment: 100 · Results not recorded
Coronary Heart Disease
Enrolment: 3002 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 48 · Results not recorded
Acute Myeloid Leukaemia · Acute Lymphocytic Leukaemia · Chronic Myeloid Leukaemia · Myelodysplastic Syndromes
Enrolment: 304 · Results not recorded
Tuberous Sclerosis · Facial Angiofibroma
Enrolment: 107 · Results not recorded
Age-Related Macular Degeneration
Enrolment: 11 · Results not recorded
15 studies reported at therapy level; 15 evidence entries itemised.
Model: Left sixth to eighth cervical preganglionic root transection, with nerve grafting plus acidic fibroblast growth factor and fibrin glue performed 3 weeks after injury
Sirolimus attenuated microglial and astrocytic proliferation and enhanced neuronal autophagy and survival. Only sirolimus-treated rats showed significant sensory and motor recovery after delayed repair, with abundant nerve fibres and neurons in the dorsal root entry zone, dorsal root ganglion and v…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: 30 percent TBSA full thickness burn
mTOR inhibition with rapamycin reduced IRS-1 serine307 phosphorylation and partly prevented burn-induced insulin resistance.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Cryogenic traumatic brain injury (cTBI)
At 3 days, rapamycin 1.5 mg/kg worsened motor deficits and increased infarct size while attenuating astrocyte reactivation, whereas 0.5 mg/kg did not worsen damage. At 7 and 14 days, 0.5 mg/kg improved motor performance and reduced glial scar area, thickness and chondroitin sulfate proteoglycan exp…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Thoracic spinal cord contusion injury
Rapamycin inhibited mTOR signalling in the injured cord and significantly improved locomotor function and reduced mechanical and thermal hypersensitivity. Iba-1 stained microglia and p38 MAPK activity in the lumbar spinal cord were significantly decreased, indicating attenuated development of neuro…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Intestinal ischaemia-reperfusion by occlusion of the superior mesenteric artery for 1 hour
Rapamycin improved survival after intestinal ischaemia-reperfusion. Intestinal injury and inflammation were similar between groups, but lung injury and inflammation were significantly attenuated, with reduced lung bacterial burden and increased alveolar macrophage phagocytic activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Moderate controlled cortical impact
A single rapamycin injection 1 h after controlled cortical impact suppressed the early neuronal peak of mTORC1 activity and significantly reduced neuronal death, astrogliosis and cognitive impairment at 1 to 3 days after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Spinal cord hemisection in mice
A single rapamycin injection reduced inflammatory cell infiltration, microglial activation and TNF-alpha secretion, limited astrocyte proliferation and GFAP expression at the lesion, and increased neuronal survival and axonogenesis towards the lesion.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Hemicerebellectomy causing remote degeneration of axotomized precerebellar neurons
Hemicerebellectomy depolarised mitochondria in axotomized precerebellar neurons with mitochondrial accumulation of PINK1, Parkin, p62 and Drp1, loss of Mfn1 and increased calcineurin activity. A single 2 mg/kg intraperitoneal dose of rapamycin increased GFP-LC3 puncta and LC3-II, reduced cytochrome…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Rapamycin reduced activated microglia and neutrophils in the damage zone, lowered TNF-alpha and IL-1beta expression, reduced apoptotic cells and increased neuronal survival after spinal cord injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute spinal cord injury induced at the T10 level
Autophagy (rising LC3II and LC3I from 10 days) preceded apoptosis (caspase-3 rising from 21 days) after injury. Rapamycin treatment improved Gale scale hind limb grades relative to vehicle control and the authors concluded that rapamycin improved prognosis by inhibiting apoptosis.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: T10 laminectomy followed by impact contusion of the spinal cord
Rapamycin improved Basso, Beattie and Bresnahan scores by day 28, increased LC3-II and reduced p70S6K phosphorylation consistent with autophagy promotion. It also lowered tumour necrosis factor production and microglial activation and preserved NeuN-positive neurons.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: acute focal cerebellar lesion causing axotomy and remote degeneration of precerebellar neurons
Cerebellar lesions activated autophagy in axotomised precerebellar neurons, and stimulating autophagy with rapamycin protected these neurons from degeneration and promoted functional recovery.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Traumatic brain injury in rats with secondary acute lung injury; specific impact model not described in the abstract
Enhancing autophagy with rapamycin suppressed apoptosis, inflammation and oxidative stress in lung tissue and improved pulmonary barrier function, oxygenation and static compliance, whereas inhibiting autophagy with 3-methyladenine aggravated these changes.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute thoracic spinal cord injury
Rapamycin increased LC3 and Beclin1 expression and Basso, Beattie and Bresnahan locomotor scores with up-regulated Bcl-2 and down-regulated Bax, whereas 3-methyladenine produced the opposite pattern.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
Model: Lung ischaemia/reperfusion injury in mice, with oxygen-glucose deprivation and restoration in human pulmonary microvascular endothelial cells
Promoting autophagy with rapamycin significantly alleviated ischaemia/reperfusion-induced lung oedema and tissue inflammation and reduced endothelial junction damage and cell death, whereas inhibiting autophagy aggravated injury.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
