A transcriptomic study of probenecid on injured spinal cords in mice.
MouseSpinal cord injuryContusionIntraperitoneal injection0.5 mg/kgImmediately after injury
Model: Contusive spinal cord injury using an Infinite Horizon impactor, 1.3 mm diameter rod at 50 Kdynes
Probenecid altered 641 genes 8 hours after contusion (286 upregulated, 355 downregulated), with enrichment for extracellular matrix and collagen trimer terms and for cell adhesion molecule, leukocyte transendothelial migration, ECM-receptor interaction and PI3K-Akt pathways. The study reported tran…
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