TRPV2 Agonists (Probenecid) in Fontan Circulation Patients
Fontan
Enrolment: 8 · Results not recorded
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Drug · Organic anion transporter (OAT1/OAT3/URAT1) inhibitor (INHIBITOR); direct interaction, disease efficacy true
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Fontan
Enrolment: 8 · Results not recorded
Healthy Subjects
Enrolment: 28 · Results not recorded
Healthy
Enrolment: 44 · Results not recorded
Healthy Adults
Enrolment: 25 · Results not recorded
Healthy
Enrolment: 45 · Results not recorded
Urinary Tract Infections · Pyelonephritis Acute · Intraabdominal Infections
Enrolment: 0 · Results not recorded
Interaction · Endogenous Biomarkers
Enrolment: 16 · Results not recorded
HIV Infections
Enrolment: 12 · Results not recorded
HIV Infections
Enrolment: 16 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Contusive spinal cord injury using an Infinite Horizon impactor, 1.3 mm diameter rod at 50 Kdynes
Probenecid altered 641 genes 8 hours after contusion (286 upregulated, 355 downregulated), with enrichment for extracellular matrix and collagen trimer terms and for cell adhesion molecule, leukocyte transendothelial migration, ECM-receptor interaction and PI3K-Akt pathways. The study reported tran…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Aristolochic acid nephropathy with proximal tubular epithelial cell necrosis, transient acute kidney injury, mononuclear infiltration, tubular atrophy and interstitial fibrosis
Probenecid prevented the rise in plasma creatinine, prevented tubulointerstitial injury, reduced the extent and severity of ultrastructural lesions and significantly reduced proliferating cell nuclear antigen positive cell numbers and total aristolochic acid-DNA adducts compared with aristolochic a…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.