Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat.
RatChemical/toxinMaleOral (mesh term Administration, Oral)50 mg/kg curcumin nanoparticles daily; doxorubicin 20 mg/kg…Pretreatment for 9 days before doxorubicin, which was injected on the 10th day…
Model: Acute doxorubicin-induced cardiotoxicity (single acute dose of doxorubicin 20 mg/kg)
Curcumin nanoparticle pretreatment prevented doxorubicin-induced tachycardia and electrocardiographic changes and normalised oxidative stress, enzyme activity and monoamine markers.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.