Influence of hydrocortisone on gentamicin-induced nephrotoxicity in rats.
RatChemical/toxinInbred strain not specifiedFemaleGiven over 3 days after the gentamicin infusion
Model: Gentamicin-induced acute tubular nephrotoxicity in infused rats
Hydrocortisone did not alter renal cortical gentamicin half-life, lysosomal phospholipidosis or histopathology, but significantly reduced the 3H/DNA ratio on day 4, indicating impaired postnecrotic tubular cell regeneration and therefore interference with recovery from aminoglycoside injury.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.