Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock: A Prospective Study
Sepsis
Enrolment: 80 · Results not recorded
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Hormone · Glucocorticoid receptor agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sepsis
Enrolment: 80 · Results not recorded
Sepsis
Enrolment: 80 · Results not recorded
Infections · Cardiac Arrest
Enrolment: 191 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Gentamicin-induced acute tubular nephrotoxicity in infused rats
Hydrocortisone did not alter renal cortical gentamicin half-life, lysosomal phospholipidosis or histopathology, but significantly reduced the 3H/DNA ratio on day 4, indicating impaired postnecrotic tubular cell regeneration and therefore interference with recovery from aminoglycoside injury.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by pancreatic duct injection of sodium taurocholate
Glycocalyx degradation appeared 3 h after onset of severe acute pancreatitis and intestinal perfusion fell significantly by 12 h, in parallel with raised superior mesenteric vein TNF-alpha. Hydrocortisone improved intestinal perfusion and reduced glycocalyx degradation.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.