CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL6/J (Charles River)MaleIntraperitoneal1 mg/kg bodyweightFirst injection at the beginning of reperfusion, immediately after the 45 minut…
Model: Transient focal cerebral ischaemia by intraluminal middle cerebral artery occlusion for 45 minutes followed by reperfusion, with inclusion requiring a laser Doppler flow drop to 20% or less
In adult (six-month-old) stroke mice, SB297006 not only reversed the aggravation of brain injury caused by ectopic CCL11 but also produced net neuroprotection relative to vehicle controls, with decreased infarct volumes, increased neuronal densities and increased post-stroke microglial activation.…
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