A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Compare GW766944 (an Oral CCR3 Receptor Antagonist) Versus Placebo in Patients With Asthma and Sputum Eosinophilia.
Asthma
Enrolment: 60 · Results not recorded
Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Asthma
Enrolment: 60 · Results not recorded
Retinal Diseases
Enrolment: 16 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Transient focal cerebral ischaemia by intraluminal middle cerebral artery occlusion for 45 minutes followed by reperfusion, with inclusion requiring a laser Doppler flow drop to 20% or less
In adult (six-month-old) stroke mice, SB297006 not only reversed the aggravation of brain injury caused by ectopic CCL11 but also produced net neuroprotection relative to vehicle controls, with decreased infarct volumes, increased neuronal densities and increased post-stroke microglial activation.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.