Protective Effect of Metformin, Resveratrol and Alpha-lipoic Acid on Radiation-Induced Pneumonitis and Fibrosis: A Histopathological Study.
MouseRadiationMalen = 80 male mice randomly allocated to eight groupsMetformin 100 mg/kg, resveratrol 200 mg/kg and alpha-lipoic…
Model: Radiation-induced pneumonitis and pulmonary fibrosis produced by a single 18 Gy dose from a cobalt-60 gamma-ray source, assessed 80 days later
Irradiation caused acute pneumonitis with inflammatory cell infiltration, alveolar and vascular damage and mild fibrosis. Metformin, alpha-lipoic acid and resveratrol each reduced pneumonitis and radiation-induced fibrosis, although the protection was described as moderate, with the authors suggest…
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