Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
MouseFractureClosed tibiaMaleIntraperitonealMorphine 4.5 mg/kg intraperitoneally; buprenorphine pretrea…One and two days after discontinuing buprenorphine and inducing the closed tibi…
Model: Closed tibial fracture producing severe acute nociceptive traumatic pain in mice previously given a chronic high dose of buprenorphine that induced mechanical allodynia
Chronic high dose buprenorphine produced significant mechanical allodynia. After closed tibial fracture, morphine at 4.5 mg/kg, a dose that is analgesic in untreated animals, failed to reduce pain in the buprenorphine group. Combining the same dose of morphine with ketamine or with ketoprofen resto…
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