Protection of sildenafil citrate hydrogel against radiation-induced skin wounds.
RatRadiationSprague-DawleyTopical5% sildenafil citrate hydrogel formulation (applied topical…After irradiation, during the acute wound healing phase
Model: Localised gamma-irradiation of skin to induce radiation skin wound and dermatitis, with a multi-dose trial over 10-55 Gy (15 Gy intervals) and a median 45 Gy dose selected for the acute wound healing studies
The 5% sildenafil citrate hydrogel significantly improved healing of 45 Gy irradiated skin relative to irradiated controls, with wound contraction of 88 plus or minus 1.02%, skin damage reduction of 81 plus or minus 0.82%, tensile strength improvement of 45 plus or minus 1.61% and nitric oxide and…
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