Drug · Phosphodiesterase 5A inhibitor (INHIBITOR)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Traumatic Brain Injury · Mild Traumatic Brain Injury · Post-Concussion Syndrome
Enrolment: 7 · Results not recorded
Pulmonary Arterial Hypertension
Enrolment: 6 · Results not recorded
Aortic Stenosis
Enrolment: 20 · Results not recorded
Impotence
Enrolment: 100 · Results not recorded
Cardiopulmonary Bypass
Enrolment: 12 · Results not recorded
Pulmonary Hypertension · COPD
Enrolment: 32 · Results not recorded
Erectile Dysfunction
Enrolment: 378 · Results not recorded
Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity
Enrolment: 44 · Results not recorded
IVF
Enrolment: 200 · Results not recorded
Active Digital Ulcers
Enrolment: 17 · Results not recorded
Erectile Dysfunction
Enrolment: 39 · Results not recorded
Erectile Dysfunction
Enrolment: 33 · Results not recorded
Obesity
Enrolment: 267 · Results not recorded
Metabolic Syndrome · Obesity
Enrolment: 46 · Results not recorded
Birth Asphyxia
Enrolment: 20 · Results not recorded
Raynaud Phenomenon
Enrolment: 10 · Results not recorded
Hand Foot Skin Reaction
Enrolment: 2 · Results not recorded
Palmar Plantar Erythrodysesthesia
Enrolment: 10 · Results not recorded
Major Depressive Disorder
Enrolment: 0 · Results not recorded
Pulmonary Hypertension, Persistent, of the Newborn
Enrolment: 1 · Results not recorded
10 studies reported at therapy level; 10 evidence entries itemised.
Model: Experimental severe head trauma (traumatic brain injury)
Sildenafil citrate significantly reduced pyknotic neuron counts and the pyknotic to total neuron ratio in both regions compared with untreated injury, with results similar to mannitol.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute radiation proctitis induced by irradiation of the rectum
Sildenafil significantly reduced histopathological injury scores and inflammatory marker immunoreactivity relative to untreated radiation proctitis, and the prophylactic regimen outperformed the therapeutic regimen histopathologically; the high-dose group behaved similarly to the prophylaxis group.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Unilateral acute retinal ischaemia-reperfusion injury induced by anterior chamber cannulation
No significant differences in electroretinography, retinal ganglion cell counts or retinal morphometry between sildenafil and saline treated experimental eyes. A non-significant tendency towards less necrosis and slightly lower PDE5, NOS2 and caspase-9 with higher Bcl-2 immunohistochemistry scores…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Three consecutive blast exposures at 22 psi causing tinnitus, auditory impairment and traumatic brain injury
Sildenafil did not prevent acute tinnitus onset or hearing impairment, but significantly suppressed high-frequency tinnitus from 3 to 6 weeks after blast exposure and reduced hearing impairment during the first week. Startle force was reduced relative to untreated blast-exposed rats, suggesting pos…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Hyperoxia-induced bronchopulmonary dysplasia-like lung injury and pulmonary hypertension: chronic hyperoxia of 75 per cent oxygen for 14 days, or acute hyperoxia of 75 per cent oxygen for 24 h followed by 13 days in room air
Sildenafil attenuated medial wall thickness and right ventricular hypertrophy and restored pulmonary artery cyclic guanosine monophosphate signalling, but did not improve mean alveolar area or vessel density.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Severe scald burn covering 30 percent of total body surface area
Sildenafil raised glutathione peroxidase, catalase and total antioxidative capacity, lowered malondialdehyde, total oxidative stress and oxidative stress index and reduced lung inflammation scores, with 10 mg/kg apparently more effective than 20 mg/kg.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Moderate contusive spinal cord injury in mice
Sildenafil increased spinal cord cyclic GMP concentrations and improved epicenter microvascular perfusion, but had no significant effect on angiogenesis at 7 days and no functional consequence for hindlimb locomotor recovery on Basso Mouse Scale or Treadscan analysis, indicating that acutely improv…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Four dorsal excisional skin defects healing by secondary intention
Sildenafil citrate gel reduced defect area from day 3, dose dependently after day 7, increased vascularity from day 3, and increased acute inflammation from day 5 with greater granulation amount and maturation and chronic inflammation from day 7.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Localised gamma-irradiation of skin to induce radiation skin wound and dermatitis, with a multi-dose trial over 10-55 Gy (15 Gy intervals) and a median 45 Gy dose selected for the acute wound healing studies
The 5% sildenafil citrate hydrogel significantly improved healing of 45 Gy irradiated skin relative to irradiated controls, with wound contraction of 88 plus or minus 1.02%, skin damage reduction of 81 plus or minus 0.82%, tensile strength improvement of 45 plus or minus 1.61% and nitric oxide and…
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.
Model: Traumatic (excisional) skin wound
The sildenafil citrate hydrogel was stable and showed no acute dermal toxicity, and increased wound contraction, re-epithelialisation and tensile strength together with higher hydroxyproline, collagen, total protein and nitric oxide content. Histopathology confirmed enhanced re-epithelialisation, c…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
