Mild Traumatic Brain Injury Causes Nociceptive Sensitization through Spinal Chemokine Upregulation.
Model: Closed-head mild traumatic brain injury delivered by a stereotaxic impactor mounted at a 40 degree angle with a 5 mm tip, impact velocity 5.8 to 6.0 m/s, dwell time 0.2 s and impact depth 5 mm over the right S1 somatosensory cortex under isoflurane anaesthesia, with no skull fractures observed; sham animals had the device discharged in air
Mild closed-head injury produced mechanical hypersensitivity peaking over 72 h and resolving by around 14 days, together with raised spinal CXCR2, CXCL1 and CXCL2 (and CXCL3 at day 7) and increased GFAP and IBA-1 staining. Intrathecal ondansetron dose-dependently reversed hypersensitivity, with the…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.