UPMC REMAP perioperative platform trial (Enhanced Recovery Protocols) incl. ondansetron 4 mg arm
Perioperative Optimization
Enrolment: 3395 · Results not recorded
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Drug · Selective 5-HT3a receptor antagonist (ANTAGONIST, direct interaction)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Perioperative Optimization
Enrolment: 3395 · Results not recorded
Breast - Female
Enrolment: 120 · Results not recorded
Pain
Enrolment: 72 · Results not recorded
Brain Function · Healthy Adults
Enrolment: 54 · Results not recorded
Nausea
Enrolment: 128 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Closed-head mild traumatic brain injury delivered by a stereotaxic impactor mounted at a 40 degree angle with a 5 mm tip, impact velocity 5.8 to 6.0 m/s, dwell time 0.2 s and impact depth 5 mm over the right S1 somatosensory cortex under isoflurane anaesthesia, with no skull fractures observed; sham animals had the device discharged in air
Mild closed-head injury produced mechanical hypersensitivity peaking over 72 h and resolving by around 14 days, together with raised spinal CXCR2, CXCL1 and CXCL2 (and CXCL3 at day 7) and increased GFAP and IBA-1 staining. Intrathecal ondansetron dose-dependently reversed hypersensitivity, with the…
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Model: Lateral fluid percussion traumatic brain injury under isoflurane anaesthesia, with a 5 mm craniotomy midway between bregma and lambda approximately 2 mm right of the midline and a pressure wave of 1.3 +/- 0.1 atm producing a mild injury; sham rats received the same procedure with no pressure wave
Traumatic brain injury caused significant mechanical allodynia in the contralateral hindpaw by 3 days post-injury lasting about 3 weeks, with less marked ipsilateral sensitisation. Intrathecal 5,7-dihydroxytryptamine given at 3 days post-injury significantly reduced sensitisation, and withdrawal th…
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Model: Cerulein-induced acute pancreatitis, induced by hourly injection of cerulein
Ondansetron significantly lowered plasma amylase, lipase and interleukin-6, attenuated histological inflammatory damage and reduced myeloperoxidase-positive neutrophil infiltration.
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