Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalen = 4 to 6 animals per experimental group (4 per group for West…Intraperitoneal0.15 to 150 mg/kg for the dose-response study (ED50 1.40 mg…Administered upon reperfusion, that is after 2 h of middle cerebral artery occl…
Model: Transient focal cerebral ischaemia by intraluminal filament occlusion of the middle cerebral artery for 2 h (or 4.5 h in the time-window experiment) followed by reperfusion
A single dose reduced ischaemic brain damage dose-dependently, cut oedema at 22 h of reperfusion (vehicle 85.7 plus or minus 19.9 mm3 versus azithromycin 25.2 plus or minus 9.6 mm3), reduced infarct volume and neurological deficit up to 7 days, remained effective when given after 4.5 h of occlusion…
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