Thymoquinone ameliorates Pachycondyla sennaarensis venom-induced acute toxic shock in male rats.
RatChemical/toxinWistarMalen = 64 male Wistar rats in total, randomly divided into four gr…Intraperitoneal for the venom; route of thymoquinone administration not statedThymoquinone 20 mg/kg; venom 600 micrograms/kgThymoquinone given 30 min after venom administration
Model: Acute toxic shock induced by sub-lethal Samsum ant (Pachycondyla sennaarensis) venom at 600 micrograms/kg intraperitoneally
Venom raised lipid peroxidation in liver and kidney by 848% and 74.5%, halved HDL, doubled cholesterol, raised urea by 70.25% and lowered IFN-gamma and IL-17, whereas thymoquinone lowered lipid peroxidation by 92.82% in liver and 23.59% in kidney, raised glutathione by 13.63% and 18.97%, restored H…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.