Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyIntravenous infusionCell number not recoverable, the exponent is missing from t…At reperfusion, after 2 hours of occlusion
Model: Middle cerebral artery occlusion for 2 hours followed by reperfusion
Intravenous F3.ChAT cells reduced infarct volume and improved cognitive and behavioural outcomes with preserved microvessels and lower oxidative and inflammatory markers, outperforming parental F3 cells.
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