THERAPY DOSSIER · th-0b71a1e1af10

Human neural stem cells encoding choline acetyltransferase (F3.ChAT)

Biologic · Genetically modified allogeneic human neural stem cell line; no ChEMBL entity expected or found. ClinicalTrials.gov searched for 'F3.ChAT' and for human neural stem cells encoding choline acetyltransferase: zero records. Confirmed zero human trials by search, not assumed.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Genetically modified allogeneic human neural stem cell line; no ChEMBL entity expected or found. ClinicalTrials.gov searched for 'F3.ChAT' and for human neural stem cells encoding choline acetyltransferase: zero records. Confirmed zero human trials by search, not assumed.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31837389 ↗2019Reported benefit

Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyIntravenous infusionCell number not recoverable, the exponent is missing from t…At reperfusion, after 2 hours of occlusion

Model: Middle cerebral artery occlusion for 2 hours followed by reperfusion

Intravenous F3.ChAT cells reduced infarct volume and improved cognitive and behavioural outcomes with preserved microvessels and lower oxidative and inflammatory markers, outperforming parental F3 cells.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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