Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke.
RatOtherSprague-Dawleymalen = 10 per group across five groupsIntravenous via femoral vein cannula5, 20 or 80 micrograms per kg body weight; antagonist L-368…60 minutes before the start of heat stress; a separate arm gave 20 micrograms/k…
Model: Experimental heat stroke, anaesthetised rats exposed to a heating pad at 42 degrees Celsius for 80 minutes, producing acute lung injury, hyperthermia and hypotension
Oxytocin pretreatment dose dependently improved survival and attenuated hyperthermia, hypotension, lung oedema, neutrophil infiltration and inflammatory and oxidative markers, effects abolished by the oxytocin receptor antagonist, whereas treatment 80 minutes after heat stress began did not affect…
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