Effect of Pulsatile Administration of Oxytocin on Desensitization of Human Myometrium In-vitro
Postpartum Hemorrhage
Enrolment: 18 · Results not recorded
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Hormone · Oxytocin receptor (OXTR) agonist; nonapeptide posterior pituitary hormone. ChEMBL mechanism mec_id 844, AGONIST, direct interaction, disease efficacy true (FDA label ref). ATC H01BB02. Black box warning present (elective labour induction).
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postpartum Hemorrhage
Enrolment: 18 · Results not recorded
Autism · Autism Spectrum Disorder
Enrolment: 51 · Results not recorded
Dysfunctional Labor
Enrolment: 0 · Results not recorded
Borderline Personality Disorder · Oxytocin
Enrolment: 100 · Results not recorded
Healthy
Enrolment: 71 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Experimental heat stroke, anaesthetised rats exposed to a heating pad at 42 degrees Celsius for 80 minutes, producing acute lung injury, hyperthermia and hypotension
Oxytocin pretreatment dose dependently improved survival and attenuated hyperthermia, hypotension, lung oedema, neutrophil infiltration and inflammatory and oxidative markers, effects abolished by the oxytocin receptor antagonist, whereas treatment 80 minutes after heat stress began did not affect…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Spinal nerve ligation with tight ligation of the right L5 and L6 spinal nerves under isoflurane anaesthesia
Hypersensitivity after spinal nerve ligation partially resolved in the postpartum period only while pups were present, cerebrospinal fluid oxytocin was higher in postpartum rats before weaning, intrathecal oxytocin reversed hypersensitivity after separation from pups, and intrathecal atosiban but n…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.