Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawleymale in the main study, female in the preliminary bone studyn = Main study: sham plus vehicle n=10, injury plus vehicle n=1…Intramuscular for testosterone enanthate; physical training for the treadmill componentTestosterone enanthate 7.0 mg per week; vehicle 0.1 mL per…Treadmill training began 1 week post-injury, treatment continued to day 56
Model: Severe thoracic contusion spinal cord injury, 250 kdyn force with an Infinite Horizon impactor
Testosterone enanthate alone attenuated cancellous bone loss and prevented levator ani/bulbocavernosus atrophy but did not improve muscle force, whereas testosterone plus treadmill training gave near complete cancellous bone preservation, prevented the soleus fibre type shift, raised peak force by…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.