Body Composition, Muscle and Bone Changes to Testosterone Therapy With or Without Finasteride After Spinal Cord Injury (TRT-SCI)
Spinal Cord Injury · Hypogonadism
Enrolment: 300 · Results not recorded
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Hormone · Long-acting testosterone ester; androgen receptor agonist.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injury · Hypogonadism
Enrolment: 300 · Results not recorded
Spinal Cord Injury · Hypogonadism
Enrolment: 33 · Results not recorded
Spinal Cord Injury · Spinal Cord Injuries · Trauma, Nervous System
Enrolment: 21 · Results not recorded
Male Hypogonadism · Muscle Atrophy · Sarcopenia · Benign Prostate Hypertrophy
Enrolment: 60 · Results not recorded
Healthy Males · Male Contraceptive
Enrolment: 11 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Severe thoracic contusion spinal cord injury, 250 kdyn force with an Infinite Horizon impactor
Testosterone enanthate alone attenuated cancellous bone loss and prevented levator ani/bulbocavernosus atrophy but did not improve muscle force, whereas testosterone plus treadmill training gave near complete cancellous bone preservation, prevented the soleus fibre type shift, raised peak force by…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Severe 250 kdyne contusion spinal cord injury; sham animals received laminectomy only
Testosterone-enanthate prevented the injury-induced loss of levator ani/bulbocavernosus muscle mass, normalised cancellous and cortical bone turnover and maintained cancellous bone mass at sham level, but produced prostate enlargement, whereas co-administered finasteride preserved these musculoskel…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.