Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress.
MouseOtherC57BL/6maleIntraperitoneal or oral gavage200 mg/kg/day
Model: Bile duct ligation, the common bile duct ligated twice with 5-0 silk and cut between the ligatures, with harvest 3 days later; in vitro glycochenodeoxycholic acid treatment of primary hepatocytes
Metformin reduced bile duct ligation induced hepatic necrosis, neutrophil infiltration, necroptosis markers, chemokines and circulating TNF-alpha alongside suppressed endoplasmic reticulum stress markers, with matching protection in primary hepatocytes.
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