Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury.
RatTBIUnspecifiedSprague-DawleyMale and femaleIntravenous injectionImmediately following traumatic brain injury
Model: Moderate-to-severe traumatic brain injury in rats; the specific injury induction method is not described in the abstract
Male rats treated with neural stem cell-derived extracellular vesicles showed significantly reduced lesion sizes, greater presence of endogenous neural stem cells and attenuated motor function impairments at 4 weeks compared with vehicle-treated and injury-only male controls. In females a therapeut…
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