THERAPY DOSSIER · th-6a0372171357

Neural stem cell-derived extracellular vesicles

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31774030 ↗2020Mixed findings

Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury.

RatTBIUnspecifiedSprague-DawleyMale and femaleIntravenous injectionImmediately following traumatic brain injury

Model: Moderate-to-severe traumatic brain injury in rats; the specific injury induction method is not described in the abstract

Male rats treated with neural stem cell-derived extracellular vesicles showed significantly reduced lesion sizes, greater presence of endogenous neural stem cells and attenuated motor function impairments at 4 weeks compared with vehicle-treated and injury-only male controls. In females a therapeut…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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