Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock.
RatHaemorrhage/shockControlledSprague DawleyMaleOne pair of bipolar electrodes attached to the cervical vagus nerve for stimulation; a second pair on the abdominal vagus nerve for action potential recordingPost-injury, after the trauma and haemorrhagic shock phase
Model: Trauma plus haemorrhagic shock with mean arterial pressure maintained at 25 mmHg for 30 min, without fluid resuscitation; cervical and abdominal vagus nerves surgically exposed under anaesthesia
Vagal nerve stimulation evoked abdominal vagal action potentials and produced an approximately two-fold increase in intestinal blood flow compared with the shock phase. Abdominal vagotomy abolished this effect. Stimulation protected against trauma and haemorrhagic shock induced gut injury and reduc…
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