Early Versus Late Vagus Stimulation for Post-stroke Motor Rehabilitation
Stroke · Motor Rehabilitation
Enrolment: 100 · Results not recorded
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Procedure
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Stroke · Motor Rehabilitation
Enrolment: 100 · Results not recorded
Rheumatoid Arthritis
Enrolment: 23 · Results not recorded
Stroke
Enrolment: 100 · Results not recorded
Gastroparesis
Enrolment: 131 · Results not recorded
Stroke Sequelae · Hemiplegia
Enrolment: 98 · Results not recorded
Depression
Enrolment: 24 · Results not recorded
Fibromyalgia
Enrolment: 87 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Trauma plus haemorrhagic shock with mean arterial pressure maintained at 25 mmHg for 30 min, without fluid resuscitation; cervical and abdominal vagus nerves surgically exposed under anaesthesia
Vagal nerve stimulation evoked abdominal vagal action potentials and produced an approximately two-fold increase in intestinal blood flow compared with the shock phase. Abdominal vagotomy abolished this effect. Stimulation protected against trauma and haemorrhagic shock induced gut injury and reduc…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Trauma and haemorrhagic shock: laparotomy with femoral artery, jugular vein and mesenteric lymphatic duct cannulation, blood withdrawn until mean arterial pressure fell to 35 +/- 5 mmHg and maintained for 60 min, then resuscitation with shed blood plus twice the shed blood volume in normal saline
Trauma and haemorrhagic shock significantly increased 35 exosomal proteins post-shock with none decreased. With vagus nerve stimulation only one protein (GAPDH, 17-fold, p < 0.01) was significantly increased. Post-shock exosomes increased monocyte NF-kappaB activity whereas post-shock exosomes from…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.