Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators.
MouseChemical/toxinICR (specific pathogen-free)Malen = 70 male ICR mice randomly divided into seven groups; per-gr…Intravenous (doxorubicin given intraperitoneally)0.5 g/kg (low), 1.5 g/kg (medium) or 5 g/kg (high); Shenmai…Pretreatment groups received Shenmai within 24 h before the first doxorubicin a…
Model: Acute cardiotoxicity induced by a cumulative intraperitoneal dose of doxorubicin 10 mg/kg given on the third experimental day, dissolved in 0.9% saline
Doxorubicin reduced heart rate, cardiac output, ejection fraction and fractional shortening, raised serum AST and LDH, increased IL-6, MCP-1, IFN-gamma and TNF, raised IKK-alpha and iNOS expression and serum nitric oxide, increased cardiac nitrotyrosine and produced myofibrillar disarrangement and…
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