THERAPY DOSSIER · th-718aa9691396

Shenmai injection, a herbal preparation containing Panax ginseng and Ophiopogon japonicus at 2 g of crude drugs per 10 mL

Nutraceutical · Multi-component herbal injection; no ChEMBL entity expected or found. FLAGGED: the intervention query returned 18 records but all were for SHENGMAI-family preparations (Shengmai capsule, Shengmai liquid, Dengzhan Shengmai, Qiqi Shengmai formula, YiQiFuMai) or unrelated acupuncture studies. Shengmai san is a related but distinct three-herb oral formula (adding Schisandra), not the two-herb Shenmai parenteral injection specified here, so no trial was recorded. Zero trials of Shenmai injection itself found on ClinicalTrials.gov via this query.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Multi-component herbal injection; no ChEMBL entity expected or found. FLAGGED: the intervention query returned 18 records but all were for SHENGMAI-family preparations (Shengmai capsule, Shengmai liquid, Dengzhan Shengmai, Qiqi Shengmai formula, YiQiFuMai) or unrelated acupuncture studies. Shengmai san is a related but distinct three-herb oral formula (adding Schisandra), not the two-herb Shenmai parenteral injection specified here, so no trial was recorded. Zero trials of Shenmai injection itself found on ClinicalTrials.gov via this query.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31744501 ↗2019Reported benefit

Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators.

MouseChemical/toxinICR (specific pathogen-free)Malen = 70 male ICR mice randomly divided into seven groups; per-gr…Intravenous (doxorubicin given intraperitoneally)0.5 g/kg (low), 1.5 g/kg (medium) or 5 g/kg (high); Shenmai…Pretreatment groups received Shenmai within 24 h before the first doxorubicin a…

Model: Acute cardiotoxicity induced by a cumulative intraperitoneal dose of doxorubicin 10 mg/kg given on the third experimental day, dissolved in 0.9% saline

Doxorubicin reduced heart rate, cardiac output, ejection fraction and fractional shortening, raised serum AST and LDH, increased IL-6, MCP-1, IFN-gamma and TNF, raised IKK-alpha and iNOS expression and serum nitric oxide, increased cardiac nitrotyrosine and produced myofibrillar disarrangement and…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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Shenmai injection, a herbal preparation containing Panax ginseng and Ophiopogon japonicus at 2 g of crude drugs per 10 mL