Dexamethasone fails to improve bleomycin-induced acute lung injury in mice.
MouseChemical/toxinNMRI outbred wild-typeMalen = Weight variation n = 3 to 21 per group; survival n = 6 to 2…Intraperitoneal injection in vivo; added to culture medium in vitro0.5 mg/kg in 100 microlitres in vivo; 100 nmol/L in vitro;…First dose given immediately after intratracheal instillation of bleomycin; in…
Model: Intratracheal instillation of bleomycin (4 U/kg, 50 microlitres) inducing acute lung injury, studied during the acute exudative phase from days 3 to 12; in vitro mechanical wound-healing assay on primary rat alveolar epithelial type II cell monolayers with bleomycin 12.5 to 200 mU/mL
Dexamethasone significantly lowered lavage TNF-alpha at day 3 but did not prevent bleomycin-induced weight loss, did not improve survival, did not reduce neutrophil infiltration, and failed to reduce lung oedema (wet/dry ratio 6.1 plus or minus 0.2 in bleomycin versus 4.6 plus or minus 0.1 in contr…
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