Decellularized brain matrix enhances macrophage polarization and functional improvements in rat spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleLocal application of hydrogel to the injured spinal cordDecellularised matrix concentrations of 1, 5 and 8 mg/mL in…
Model: Contusion spinal cord injury model in rats, described as acute spinal cord injury; accompanying in vitro cultures of primary macrophages and cortical and hippocampal neurons
Hydrogels promoted M2 macrophage polarisation and neurite outgrowth in vitro. In the rat spinal cord injury model the M1 to M2 macrophage balance was substantially altered, and at 5 mg/mL the expression of M2-associated molecules was significantly increased. Total macrophage population and lesion c…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.