THERAPY DOSSIER · th-d347c28ffa27

Porcine brain decellularised extracellular matrix hydrogel formulated with collagen

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31711898 ↗2019Reported benefit

Decellularized brain matrix enhances macrophage polarization and functional improvements in rat spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleLocal application of hydrogel to the injured spinal cordDecellularised matrix concentrations of 1, 5 and 8 mg/mL in…

Model: Contusion spinal cord injury model in rats, described as acute spinal cord injury; accompanying in vitro cultures of primary macrophages and cortical and hippocampal neurons

Hydrogels promoted M2 macrophage polarisation and neurite outgrowth in vitro. In the rat spinal cord injury model the M1 to M2 macrophage balance was substantially altered, and at 5 mg/mL the expression of M2-associated molecules was significantly increased. Total macrophage population and lesion c…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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