Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.
MouseSpinal cord injuryContusionC57BL/6J; plasminogen-deficient B6.129S2 line on C57BL/6J backgroundFemalen = n = 15 per group for BMS and rotarod; n = 7 per group for L…Intravenous bolus, followed in some groups by oral administration in drinking water100 mg/kg bolus in saline; continuous dosing via drinking w…Bolus given immediately after contusion
Model: Contusion spinal cord injury; T10 laminectomy and Infinite Horizons impactor at 60 kdyn; sham mice received laminectomy only
Short-term tranexamic acid, given as an intravenous bolus plus 3 days of oral dosing, significantly improved BMS and rotarod scores versus saline (p = 0.004 and p = 0.005), reduced fibrous scar area, increased myelin sparing, lowered blood-spinal cord barrier permeability at 1 dpi and suppressed TN…
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