Revision Total Hip Arthroplasty: Intravenous vs Topical Tranexamic Acid (VITALITY-X)
Blood Loss, Surgical · Arthroplasty, Replacement, Hip
Enrolment: 160 · Results not recorded
Loading the evidence…
Drug · Plasminogen inhibitor (INHIBITOR), direct interaction, disease efficacy true; antifibrinolytic.
13 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Blood Loss, Surgical · Arthroplasty, Replacement, Hip
Enrolment: 160 · Results not recorded
Perioperative Blood Loss
Enrolment: 45 · Results not recorded
Blood Loss, Surgical · Blood Loss Anemia
Enrolment: 83 · Results not recorded
Blood Loss · Hip Arthritis · Knee Arthritis
Enrolment: 246 · Results not recorded
Perioperative Bleeding · Venous Thrombosis · Arterial Thrombosis
Enrolment: 9535 · Results not recorded
Chronic Kidney Diseases · Acute Kidney Injury · Bleeding · Surgery
Enrolment: 100 · Results not recorded
Hip Fracture
Enrolment: 110 · Results not recorded
Spinal Deformity · Blood Loss, Surgical
Enrolment: 100 · Results not recorded
Post Partum Hemorrhage
Enrolment: 345 · Results not recorded
Fracture Humerus
Enrolment: 0 · Results not recorded
Rotator Cuff Tears · Surgical Blood Loss
Enrolment: 72 · Results not recorded
Postpartum Hemorrhage · Hyperfibrinolysis
Enrolment: 34 · Results not recorded
Hemorrhage
Enrolment: 80 · Results not recorded
Cardiac Surgery
Enrolment: 955 · Results not recorded
Lumbar Spinal Stenosis · Thoracic Spinal Stenosis
Enrolment: 29 · Results not recorded
Melasma
Enrolment: 50 · Results not recorded
Uterine Fibroid
Enrolment: 60 · Results not recorded
Menorrhagia
Enrolment: 17 · Results not recorded
Myoma
Enrolment: 100 · Results not recorded
Acute Aortic Dissection
Enrolment: 220 · Results not recorded
9 studies reported at therapy level; 9 evidence entries itemised.
Model: 40% total body surface area full-thickness scald burn, 80 degrees C water for 30 s, with intraperitoneal lactated Ringer resuscitation
Tranexamic acid and the topical p38 MAPK inhibitor each reduced circulating mitochondrial DNA and lung macrophage infiltration at 5 h, but neither reduced syndecan-1 shedding and their combination gave no additional benefit.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Murine tail bleeding assay; swine junctional haemorrhage by femoral arteriotomy without compression; in vitro clot lysis assays
Self-propelled tranexamic acid was more effective than non-propelled formulations at stabilising clots from lysis in vitro and at reducing blood loss in mice. When incorporated into gauze, four of six pigs treated after femoral arteriotomy without compression survived, and systemic tranexamic acid…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Contusion spinal cord injury; T10 laminectomy and Infinite Horizons impactor at 60 kdyn; sham mice received laminectomy only
Short-term tranexamic acid, given as an intravenous bolus plus 3 days of oral dosing, significantly improved BMS and rotarod scores versus saline (p = 0.004 and p = 0.005), reduced fibrous scar area, increased myelin sparing, lowered blood-spinal cord barrier permeability at 1 dpi and suppressed TN…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Polytrauma consisting of laparotomy, three crush injuries to each of the left and medial liver lobes, ten crush injuries to a 10 cm section of small intestine at the proximal cecum, a closed right femur fracture produced by dropping six 65 g steel balls from 36 inches through a guide tube, and ten crushes of right leg skeletal muscle; followed by haemorrhage to a mean arterial pressure of 40 mmHg until 40 per cent of estimated blood volume was removed. All groups received limited fresh whole blood resuscitation at 60 min after trauma (20 per cent of blood volume, 50 per cent of shed volume).
Tranexamic acid given before trauma inhibited the rise in prothrombin time at 30 min, delaying the onset of acute traumatic coagulopathy from 30 to 120 min, and significantly lowered plasma D-dimer and the plasmin(ogen)/fibrin(ogen) ratio in traumatised liver relative to vehicle and to tranexamic a…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Moderate contusion spinal cord injury (70 kdyn) at the 9th thoracic level using an Infinite Horizons Impactor under pentobarbital anaesthesia (75 mg/kg intraperitoneally); separate experiments injected packed or lysed red blood cells or haem solution (125 or 250 microM, 2 microL at 1 microL/min) into naive spinal cord at T9
Tranexamic acid given immediately after contusion spinal cord injury significantly reduced intralesional red blood cell volume, bleeding area, haem content and demyelinated area compared with saline, whereas heparin worsened these measures. Tranexamic acid also reduced TLR4, TNF, MyD88 and NF-kB p6…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Trauma-haemorrhagic shock with femoral artery blood withdrawal holding blood pressure at 30 mmHg for 90 min, producing acute lung injury
Tranexamic acid at both doses before injury, and 100 mg/kg after injury, improved survival, reduced lung permeability and suppressed pulmonary inflammation and PARP1/NF-kappa B signalling.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Weight-drop spinal cord injury at the 12th thoracic vertebra
Compared with control, the triple therapy significantly reduced parenchymal haemorrhage (p < 0.05) and increased the total amount of intact neural tissue at 24 h (p = 0.003).
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Haemorrhagic shock, bled to a mean arterial pressure of 35 plus or minus 5 mmHg and maintained for 90 minutes
Intraluminal tranexamic acid significantly reduced gut and lung histopathological injury and inflammation compared with haemorrhagic shock alone. ADAM-17 and TNF alpha in gut, lung and the systemic circulation were significantly increased by haemorrhagic shock and lessened by tranexamic acid, and g…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Polytrauma (laparotomy with trauma to intestines, liver and right leg skeletal muscle, plus right femur fracture) followed by controlled haemorrhage of 40% blood volume and resuscitation
Polytrauma with haemorrhage and fresh whole blood resuscitation raised lung water content, which was significantly reduced by added tranexamic acid. Tranexamic acid further reduced lung neutrophil and monocyte counts, neutrophil elastase and complement C5a beyond fresh whole blood alone. Lung plasm…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.