Is all plasma created equal? A pilot study of the effect of interdonor variability.
MixedHaemorrhage/shockControlledC57BL/6JMalen = n = 6-7 per group in vivo; plasma from 24 donors in vitro (…Intravascular via femoral arterial cannula1x shed blood volumeAfter the 90-minute shock period; haemodynamics tracked 30 minutes after resusc…
Model: Trauma-haemorrhagic shock; midline laparotomy with intestinal inspection, femoral artery cannulation, then bleeding to mean arterial pressure of 35 +/- 5 mmHg maintained for 90 minutes
Plasma from 24 healthy donors varied markedly in its ability to reverse endothelial hyperpermeability, and the more protective unit had far lower syndecan-1 than the less protective unit (231 +/- 172 versus 38427 +/- 1257 pg/mL). In mice resuscitated after haemorrhagic shock, the more protective pl…
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