THERAPY DOSSIER · th-d4f40b0395ff

Human donor plasma (resuscitation fluid)

Biologic · Human donor plasma used as resuscitation fluid; blood product.

Evidence & regulatory context

Mechanism: Human donor plasma used as resuscitation fluid; blood product.
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07212998 ↗Injury indicationPHASE3not yet recruiting

Plasma Resuscitation Early (PREEVEnT) Trial in Thermal Injury

Burn Injury · Thermal Burn

Enrolment: 750 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31688783 ↗2020Mixed findings

Is all plasma created equal? A pilot study of the effect of interdonor variability.

MixedHaemorrhage/shockControlledC57BL/6JMalen = n = 6-7 per group in vivo; plasma from 24 donors in vitro (…Intravascular via femoral arterial cannula1x shed blood volumeAfter the 90-minute shock period; haemodynamics tracked 30 minutes after resusc…

Model: Trauma-haemorrhagic shock; midline laparotomy with intestinal inspection, femoral artery cannulation, then bleeding to mean arterial pressure of 35 +/- 5 mmHg maintained for 90 minutes

Plasma from 24 healthy donors varied markedly in its ability to reverse endothelial hyperpermeability, and the more protective unit had far lower syndecan-1 than the less protective unit (231 +/- 172 versus 38427 +/- 1257 pg/mL). In mice resuscitated after haemorrhagic shock, the more protective pl…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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