A Frog-Derived Immunomodulatory Peptide Promotes Cutaneous Wound Healing by Regulating Cellular Response.
MouseWoundBALB/cFemalen = n = 6 mice per group for the wound model and histologyTopical application to the wound20 microlitres per wound at 200 micrograms/mLTreatment began on the day of wounding (day 0)
Model: Full-thickness dorsal skin wound created with an 8 mm biopsy punch under sodium pentobarbital anaesthesia
Topical Ot-WHP significantly accelerated full-thickness wound repair relative to PBS, with healing rates of 67.7, 81.5, 84.8 and 88.5 per cent at days 2, 4, 6 and 8, comparable to the AH90 and EGF positive controls, while scrambled peptide had no effect. Histology showed improved epidermal regenera…
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